GNOME 3: Lock and unlock the screen from the commandline

# Lock
dbus-send --session --dest=org.gnome.ScreenSaver --type=method_call --print-reply --reply-timeout=20000 /org/gnome/ScreenSaver org.gnome.ScreenSaver.SetActive boolean:true

# Unlock
dbus-send --session --dest=org.gnome.ScreenSaver --type=method_call --print-reply --reply-timeout=20000 /org/gnome/ScreenSaver org.gnome.ScreenSaver.SetActive boolean:false

Notes - GNOME